Journal: PLoS Genetics
Article Title: Network Analysis of a Pkd1 -Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier
doi: 10.1371/journal.pgen.1003053
Figure Lengend Snippet: A) Representative kidney histology (H&E stain; scale bar: 500 mm); B) PCA plot: genotype and age explain most of the clustering in the complete set of 70 kidneys in the early-onset model (control: red; mutant: blue; size of spheres: age). C and D) Heatmap plot of mutant-signature (genes in ) in the test (C) and validation (D) groups. E) Heatmap plot of ME2 (genes in ) cluster in the validation group.
Article Snippet: For both mRNA and microRNA normalized data, Partek was used to obtain principal component analysis and heatmap plots, and to identify differentially expressed probes/genes using ANOVA-based methods and fdr multiple comparison correction.
Techniques: Staining, Control, Mutagenesis, Biomarker Discovery